USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q8NEZ4 USC-OGP 2-DE database:  Q8NEZ4 Q8NEZ4 General information about the entry View entry in simple text format Entry name MLL3_HUMAN Primary accession number Q8NEZ4 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Histone-lysine N-methyltransferase 2C; Short=Lysine N-methyltransferase 2C; EC=2.1.1.43; AltName: Full=Homologous to ALR protein; AltName: Full=Myeloid/lymphoid or mixed-lineage leukemia protein 3;. Gene name Name=KMT2C Synonyms=HALR, KIAA1506, MLL3 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1168: pI=6.99; Mw=47770 Cross-references UniProtKB/Swiss-Prot Q8NEZ4; KMT2C_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KMT2C_HUMAN Primary accession number Q8NEZ4 Secondary accession number(s) Q8NC02 Q8NDF6 Q9H9P4 Q9NR13 Q9P222 Q9UDR7 Sequence was last modified on  January 20, 2009 (version 3) Annotations were last modified on  March 15, 2017 (version 158) Name and origin of the protein Description RecName: Full=Histone-lysine N-methyltransferase 2C; Short=Lysine N-methyltransferase 2C; EC=2.1.1.43; AltName: Full=Homologous to ALR protein; AltName: Full=Myeloid/lymphoid or mixed-lineage leukemia protein 3; Gene name Name=KMT2C Synonyms=HALR, KIAA1506, MLL3 Encoded on Name=KMT2C; Synonyms=HALR, KIAA1506, MLL3 Keywords 3D-structure; Acetylation; Activator; Acyltransferase; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Lipoprotein; Metal-binding; Methylation; Methyltransferase; Nucleus; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AY024361; AAK00583.1; -; mRNA EMBL AF264750; AAF74766.2; -; mRNA EMBL AC006017; AAD45822.1; -; Genomic_DNA EMBL AC104692; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC005631; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AB040939; BAA96030.2; -; mRNA EMBL AK022687; -; NOT_ANNOTATED_CDS; mRNA EMBL AK075113; BAC11409.1; -; mRNA EMBL AL833924; CAD38780.1; -; mRNA CCDS CCDS5931.1; -. [Q8NEZ4-1]; . RefSeq NP_733751.2; NM_170606.2. [Q8NEZ4-1]; . UniGene Hs.647120; -; . PDB 2YSM; NMR; -; A=342-439 PDB 2YUK; NMR; -; A=1631-1713 PDB 3UVL; X-ray; 2.20 A; B=4707-4717 PDB 4ERY; X-ray; 1.30 A; D=4703-4716 PDB 5F59; X-ray; 2.80 A; A=4757-4910 PDB 5F6K; X-ray; 2.41 A; C/E=4757-4911 PDBsum 2YSM; -; . PDBsum 2YUK; -; . PDBsum 3UVL; -; . PDBsum 4ERY; -; . PDBsum 5F59; -; . PDBsum 5F6K; -; . ProteinModelPortal Q8NEZ4; -; . SMR Q8NEZ4; -; . BioGrid 121835; 24; . DIP DIP-48649N; -; . IntAct Q8NEZ4; 18; . MINT MINT-3042700; -; . STRING 9606.ENSP00000262189; -; . BindingDB Q8NEZ4; -; . ChEMBL CHEMBL2189113; -; . iPTMnet Q8NEZ4; -; . PhosphoSitePlus Q8NEZ4; -; . BioMuta KMT2C; -; . DMDM 221222521; -; . EPD Q8NEZ4; -; . MaxQB Q8NEZ4; -; . PaxDb Q8NEZ4; -; . PeptideAtlas Q8NEZ4; -; . PRIDE Q8NEZ4; -; . Ensembl ENST00000262189; ENSP00000262189; ENSG00000055609. [Q8NEZ4-1]; . Ensembl ENST00000355193; ENSP00000347325; ENSG00000055609. [Q8NEZ4-1]; . GeneID 58508; -; . KEGG hsa:58508; -; . UCSC uc003wla.3; human. [Q8NEZ4-1]; . CTD 58508; -; . DisGeNET 58508; -; . GeneCards KMT2C; -; . H-InvDB HIX0007238; -; . H-InvDB HIX0016202; -; . H-InvDB HIX0080234; -; . HGNC HGNC:13726; KMT2C; . HPA HPA074736; -; . MIM 606833; gene; . neXtProt NX_Q8NEZ4; -; . OpenTargets ENSG00000055609; -; . PharmGKB PA30847; -; . eggNOG KOG4443; Eukaryota; . eggNOG COG2940; LUCA; . GeneTree ENSGT00760000119228; -; . HOVERGEN HBG045586; -; . InParanoid Q8NEZ4; -; . KO K09188; -; . OMA MPSLPGW; -; . OrthoDB EOG091G000H; -; . PhylomeDB Q8NEZ4; -; . TreeFam TF354317; -; . Reactome R-HSA-3214841; PKMTs methylate histone lysines; . Reactome R-HSA-5617472; Activation of anterior HOX genes in hindbrain development during early embryogenesis; . EvolutionaryTrace Q8NEZ4; -; . GeneWiki MLL3; -; . GenomeRNAi 58508; -; . PRO PR:Q8NEZ4; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000055609; -; . CleanEx HS_MLL3; -; . ExpressionAtlas Q8NEZ4; baseline and differential; . Genevisible Q8NEZ4; HS; . GO GO:0035097; C:histone methyltransferase complex; IDA:MGI; . GO GO:0044666; C:MLL3/4 complex; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:MGI; . GO GO:0003677; F:DNA binding; IEA:UniProtKB-KW; . GO GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:MGI; . GO GO:0018024; F:histone-lysine N-methyltransferase activity; TAS:Reactome; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0016746; F:transferase activity; transferring acyl groups; IEA:UniProtKB-KW GO GO:0008270; F:zinc ion binding; IEA:InterPro; . GO GO:0006355; P:regulation of transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW Gene3D 3.30.40.10; -; 6; . InterPro IPR003889; FYrich_C; . InterPro IPR003888; FYrich_N; . InterPro IPR009071; HMG_box_dom; . InterPro IPR000637; HMGI/Y_DNA-bd_CS; . InterPro IPR003616; Post-SET_dom; . InterPro IPR001214; SET_dom; . InterPro IPR011011; Znf_FYVE_PHD; . InterPro IPR001965; Znf_PHD; . InterPro IPR019787; Znf_PHD-finger; . InterPro IPR001841; Znf_RING; . InterPro IPR013083; Znf_RING/FYVE/PHD; . Pfam PF05965; FYRC; 1; . Pfam PF05964; FYRN; 1; . Pfam PF00628; PHD; 2; . Pfam PF00856; SET; 1; . SMART SM00542; FYRC; 1; . SMART SM00541; FYRN; 1; . SMART SM00398; HMG; 1; . SMART SM00249; PHD; 8; . SMART SM00508; PostSET; 1; . SMART SM00184; RING; 4; . SMART SM00317; SET; 1; . SUPFAM SSF47095; SSF47095; 1; . SUPFAM SSF57903; SSF57903; 6; . PROSITE PS50216; DHHC; 1; . PROSITE PS51805; EPHD; 2; . PROSITE PS51543; FYRC; 1; . PROSITE PS51542; FYRN; 1; . PROSITE PS00354; HMGI_Y; 1; . PROSITE PS50868; POST_SET; 1; . PROSITE PS50280; SET; 1; . PROSITE PS01359; ZF_PHD_1; 5; . PROSITE PS50016; ZF_PHD_2; 6; . PROSITE PS50089; ZF_RING_2; 1; .

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